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M94A3058.TXT
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1994-10-25
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Document 3058
DOCN M94A3058
TI Heterosexual transmission of HIV in Rio de Janeiro: immunological
aspects.
DT 9412
AU Morgado M; Guimaraes MD; Neves Junior I; Castilho E; Department of
Immunology (IOC-FIOCRUZ), Rio de Janeiro, Brasil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):163 (abstract no. PB0077). Unique
Identifier : AIDSLINE ICA10/94369517
AB OBJECTIVE: To evaluate immunological aspects among female partners (FP)
of HIV infected male index cases (IC) in Rio de Janeiro, Brazil.
METHODS: ICs and their FPs were recruited from participant centers in
Rio de Janeiro, Brazil. They should be sexually active within the past
year and female partners should not have other risk factor for HIV.
Couples were interviewed for risk factors and had blood collected for
exams: HIV(ELISA & WB); CD4, CD8, CD2 and CD19 phenotyping (Flow
Cytometry) and immunoglobulins determinations (IgA, IgG, IgM). Analysis
included: student's t-test, Odds Ratio (OR) with 95% confidence limits.
RESULTS: As of Dec 1993, 340 couples had been recruited, with 48% of the
FP HIV positive. Among the ELISA seronegative women, 5(2.8%) showed
positive reaction to gp 120-160 and/or gp 41 envelope proteins in the WB
test. Indeterminate WB with positive reaction to p24(6.3%), p55/51
and/or p66(2.3%) and p17(1.7%) were also observed. Follow-up of these
women, as well as those with negative ELISA and WB, are under evaluation
in order to assess seroconvertion rate. No difference in mean value of B
lymphocytes (CD19+) was verified among HIV positive or negative women (p
= .202). However, mean concentration of IgG, IgM and IgA were
significantly higher among positive as compared to negative women (p
values of .000, .001 and .013, respectively). No significant association
with HIV infection among the FP was observed when comparing CD4+ cell
count (< 200 vs 500+/mm3) or CD4+/CD8+ ratio (< .8 vs > or = .8) (OR =
.92, 95% CI = .48-1.77 and OR = 1.43, 95% CI = .84-2.45, respectively).
Nevertheless, among concordant positive couples, mean values of CD4+
absolute cell count and CD4+/CD8+ ratio were lower among the ICs as
compared to their FPs (CD4+ = 297 and 473mm3/; CD4+/CD8+ ratio = .53 and
1.03, respectively). CONCLUSIONS: 1. Considering that positivity to env
proteins are highly predictive for seroconvertion, the sensibility of
the ELISA test was only 96.9% for this high risk group; 2. Lower levels
of CD4+ cell count and CD+/CD8+ ratio among the index cases indicate
early infection in the male group; 3. The lack of association between
CD4+ absolute count or CD4+/CD8+ ratio and HIV infection among the women
will be further investigated in this population.
DE AIDS Serodiagnosis Biological Markers/*BLOOD Brazil *Developing
Countries Female Human HIV Antibodies/BLOOD HIV Antigens/IMMUNOLOGY
HIV Infections/*IMMUNOLOGY/TRANSMISSION HIV Seronegativity/IMMUNOLOGY
HIV Seropositivity/IMMUNOLOGY/TRANSMISSION Immunoglobulins/BLOOD
Leukocyte Count Male Risk Factors Sex Behavior *Sexual Partners
T-Lymphocyte Subsets/IMMUNOLOGY *Urban Population MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).